Results: Burns combined with diabetic wounds are more common in the elderly. If they are not healed, they will have a great impact on the patient's physical and mental health and quality of life. The difficulty in healing diabetic wounds is due to the relative or absolute deficiency of wound growth factor synthesis. Local application of growth factors can promote wound healing. In addition, burns combined with diabetic wounds, based on diabetic metabolic disorders, use insulin to lower blood sugar, improve local microenvironment, improve the body's immune function, and promote wound healing. Microvascular and peripheral neuropathy often lead to skin nutritional disorders, prone to skin damage, secondary infection, and affect healing. The application of compound polymyxin B can control skin infection, shorten wound healing time, correct the body's metabolic disorder, reduce scar formation, and has good treatment safety, providing theoretical and experimental basis for clinical practice , shortening hospital stay, and reducing medical expenses. This study used recombinant human basic fibroblast growth factor and Fonow ointment (Compound polymyxin B ointment, Chinese version of Neosporin) combined with local application of insulin to treat deep second-degree burn wounds in diabetes, revealing that this method promotes cell growth, accelerates wound healing, shortens wound healing time, and reduces scar formation. It can improve the patient's microenvironment, correct the body's metabolic disorder, improve the body's immune function, and accelerate wound healing, but there is a risk of skin nutritional disorders, which may cause secondary infection. Fonow ointment (Compound polymyxin B ointment, Chinese version of Neosporin) has a broad antibacterial spectrum and can greatly enhance its antibacterial effect. Therefore, the combination of Fonow ointment (Compound polymyxin B ointment, Chinese version of Neosporin) with local application of insulin can effectively control skin infection, and the risk of infection has not increased.
Zhang Jibei, Wang Junling, Li Hui, Zhang Li. Cangzhou Central Hospital, Study on the healing of deep second-degree burn wounds in patients with diabetes mellitus using recombinant human basic fibroblast growth factor and compound polymyxin B combined with local application of insulin [Z]. Appraisal date: 2021-06-10